Anything that gets int he way of Christ is a "loss" to us, because it harms faith. Gaining Christ means knowing him and knowing that his resurrection is our source of confidence.
Jesus makes it clear the the way of salvation includes suffering - suffering in which we deny self, confident that God has already given us everything we need.
The First Commandment. We see in Abraham's example our own glaring failures to fear, love, and trust in God above all things, yet the Lord provides forgiveness for us.